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These changes are supported by fundamental metabolic reprogramming that enables neurons to meet increasing energy and biosynthetic demands

5.3 Supplementing the endogenous and exogenous antioxidants The primary endogenous antioxidants in mammalian cells include NAD, GSH, and vitamin C, which collectively shield cells from oxidative stress

10.1074/jbc.R800045200 102 MaassF.MichalkeB.WillkommenD.SchulteC.TngesL.BoergerM.et al (2020)

BNIP3 induction by hypoxia stimulates FASN-dependent free fatty acid production enhancing therapeutic potential of umbilical cord blood-derived human mesenchymal stem cells

Here, it binds to antioxidant-responsive elements, initiating the transcription of various antioxidant genes [such as NAD(P)H:quinone oxidoreductase 1, glutathione S-transferase, heme oxygenase 1, -glutamylcysteine ligase and GSH] (58)