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Ng and colleagues (2000) demonstrated that the fragment stimulated lipolysis in isolated rat adipocytes with potency comparable to full-length hGH, while failing to elicit growth-promoting or glucose-disrupting effects

rFGF21 treatment failed to reduce mitochondrial damage and neuronal death upon SLC25A39 knockdown in primary neuron To elucidate the involvement of SLC25A39 in the protective effects of FGF21 on mitochondrial integrity and neuronal viability, we employed adenovirus-mediated siRNA technology to knock down SLC25A39 in primary neurons