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Lally JSV, Ghoshal S, DePeralta DK, Moaven O, Wei L, Masia R, Erstad DJ, Fujiwara N, Leong V, Houde VP, Anagnostopoulos AE, Wang A, Broadfield LA, Ford RJ, Foster RA, Bates J, Sun H, Wang T, Liu H, Fuchs BC (2019) Inhibition of acetyl-CoA carboxylase by phosphorylation or the inhibitor ND-654 suppresses lipogenesis and hepatocellular carcinoma

Therefore, NFE2L2 serves a crucial role in the transcriptional regulation of ferroptosis, primarily via the activation of genes that counteract cellular damage (61)

The unbalanced regulation of the glutathione synthesis coupled with the rapid and steady increase of glutathione abundance in the wheat tissue of the infested resistant plants suggested that the -glutamylcysteine synthetase might be either inhibited by a negative feedback from GSH, or it is not the rate-limiting enzyme in the glutathione synthetic pathway in wheat plants under our experimental conditions

These pairings tend to recur in the literature because their mechanisms dont overlap, allowing researchers to isolate each compounds contribution to a shared outcome

PMID: 28 DevasundaramS.DeenadayalanA.RajaA