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Abbreviations 4AP: 4-aminopyridine Ad: Adiponectin APJ: Angiotensin-like 1 receptor APLN: Apelin AT: Adipose tissue BAT: Brown adipose tissue BeAT: Beige adipose tissue BBB: Blood brain barrier BK: Large conductance calcium-activated potassium CFS: Complex febrile seizure CNS: Central nervus system COX: Cyclooxygenase CSF: Cerebrospinal fluid DRE: Drug-resistant epilepsy EPSCs: Excitatory postsynaptic currents eNOS: Endothelial nitric oxide synthase FC: Febrile Illness Without seizure/ febrile control FS: Febrile seizure GFAP: Glial fibrillary acidic protein GCs: Glucocorticoids HC: Healthy control i.c.v: Intracerebroventricularly KA: Kainic acid KD: Ketogenic diet LTP: Long-term depression MS: Multiple sclerosis NYP: Neuropeptide Y NF: Kb-Nuclear factor kappa PTZ: Pentylenetetrazole ROS: Reactive oxygen species STAT: Signal transducer and activator of transcription 3 TLE: Temporal lobe epilepsy Trkb: Tyrosine kinase receptor B VEGF: Vascular endothelial growth factor WAT: White adipose tissue WT: Wild-type References Kanmounye US, Abu-Bonsrah N, Shlobin NA, Djoutsop OM (2022) Letter: the World Health Organizations Intersectoral Global Action Plan on Epilepsy and Other Neurological disorders 20222031

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Enhancing the gut microbiome through probiotics and a healthy diet may improve glymphatic system function and brain health, thereby preventing cognitive disorders