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XL: Investigation, Methodology, Software, Validation, Writing review & editing

While brain interstitial fluid tau concentrations are reported to be nearly twice as high during the active period of the rest-activity cycle in humans [8], it is noteworthy that, to the best of our knowledge, no study has investigated whether the deletion of core clock genes, simulating circadian disruption, leads to an increase in tau hyperphosphorylation

Genetic basis for a mouse model of Down syndrome

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