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Trends in Endocrinology and Metabolism, 25 (5), 255262

Importantly, of all the metabolites that significantly distinguished +ADT from ADT group, the only metabolite that significantly correlated with PROMIS-SRI sleep impairment T -scores was androsterone sulfate, which is a metabolic endpoint marker of the effectiveness of ADT in reducing circulating androgens ( via alterations in the androgenic action on SCN circuitry and circadian rhythmicity