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*Correspondence: Martin Joyce-Brady, The Pulmonary Center, Boston University School of Medicine, 715 Albany Street, R304, Boston, MA 02118, USA e-mail: [email protected] This article was submitted to Experimental Pharmacology and Drug Discovery, a section of the journal Frontiers in Pharmacology

Dysbiosis amplifies barrier dysfunction and immune activation, while inflammation further perturbs microbial composition and impairs epithelial repair, establishing a self-sustaining pathological cycle

Funding We appreciate the funding support from National Institutes of Health (NIH) award RHL143545-01A1

The American Osteopathic College of Dermatology recommend using hydroquinone with a strong sunscreen

This charge disappears as the molecules change to NADH or NADPH