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Animal research and scarce human studies confirm these findings, showing that disruptions in microbiota composition or metabolite profiles can induce anxiety-like behaviors via MGBA (Cai et al., 2025)

Blood pressure and glaucoma: at the crossroads between cardiology and ophthalmology

Furthermore, for the efficient transporter-mediated permeation across the BBB, the prodrugs must be able to bind also to the intracellular substrate binding site of the transporter at the abluminal membrane of the brain capillary endothelial cells and to be translocated out of the endothelial cells into the ECF and, subsequently, to the brain parenchyma through the targeted transporter (Figs

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Subsequently, the PBLA block of the polymer was aminolyzed by diethylethylenediamine (DEA), histamine (His), and N , N -diisopropylamino ethylamine (DIP) at a molar ratio of 20:10:55 to endow the nanocarrier with a sensitivity to the acidic tumor 26