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But most over-the-counter B12 supplements contain far more in the range of 500 to 1,000 micrograms, she says, adding, That sounds pretty excessive, but its actually intentional since oral B12 absorption is inefficient

10.1186/s12967-024-06019-4 84 LuJ.LiuZ.ShuM.ZhangL.XiaW.TangL.et al (2021)

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This idea posits that excessive dopaminergic activity in the course of mania precipitates dopamine receptor down-regulation, which subsequently triggers a transition into a depressed state (245)