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Dysregulated glucose metabolism is well reported in humans and animal models of ALS 13,29 , with increased production of lactate, a hallmark of the Warburg effect 25 , emerging as an early disease event

CK, creatine kinase

Sometimes, pieces of the clots can break off, lodge in vessels, and cause life-threatening obstruction of blood flow to the brain or other vital organs, thereby compromising their function

Bruce Merrifield, involves attaching the C-terminus of the peptide chain to a polymeric solid, usually having the form of very small beads

In rats, preferential affinity for the MOP-1r relative to the MOP-2r subtype has been proposed as a possible explanation for the reduced degree of respiratory depression compared to morphine, but there are remarkable discrepancies in the findings of different studies [112, 120, 121] (Table 2)