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Upon completion of the modeling process, 3 rats from the group that underwent modeling and 3 from the control group were randomly selected for preliminary evaluation to confirm the successful establishment of the KOA model

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the authors hypothesized a change in the balance between thyroid hormone biosynthesis and elimination (97) an induction of microsomal enzymes as uridine diphosphate glucuronosyltransferase, and an increased T4 to T3 conversion by inducing deiodinase (98, 99)

Throughout the study, the animals were provided a standard pellet feed and water ad libitum

Certain foods, particularly those high in fat, can affect the absorption of the medication, potentially altering its intended effects