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11,12 Notably, sporadic CRC, which represent the majority of CRC cases, exhibit extensive inflammatory infiltrates with high levels of cytokine expression in the tumor microenvironment

Jun 2010;52(2 Suppl 1):63-7

Burrows (1979) found that toluidine blue given intravenously to sheep at a dose of 1.1 mg/kg reduced methaemoglobin produced by sodium nitrite, although the rate of reduction could be increased by the use of higher doses