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The combination creates a dual mechanism: naltrexone reduces food reward and craving intensity, while bupropion enhances the brain's satiety signals and provides mild stimulant-like appetite suppression

CagriSema dosing protocols show that combining medications targeting different pathways may achieve results exceeding either component alone

41 Hvas, A.-M., Juul, S., Lauritzen, L., Nex, E

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