glutathione-dependent antioxidant system Effect of nitrite exposure on the enzymes and glutathione in the liver of bighead carp, Aristichthys nobilis Role of Glutathione in Cancer:

2.3 Cisplatin induces mitochondrial dysfunction When cisplatin enters the mitochondria, it acts directly on the inner mitochondrial membrane, leading to the impairment of the function of the electron transport chain, the reduction of ATP production and the induction of ROS generation (Tan and Song, 2023),these damages further lead to mitochondrial dysfunction, which in turn prompts more ROS production, forming a positive feedback loop (Tan and Vlajkovic, 2023)

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after four to five half-lives, less than 5% remains, which is usually the point at which pharmacological effects are considered negligible

Vascular permeability factor/vascular endothelial growth factor: a critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy