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& Guizzaro, L

The initiation of ferroptosis involves the depletion of GSH, an essential cellular antioxidant, which leads to the accumulation of toxic lipid ROS and eventual cell death (Tang et al., 2021)

Furthermore, that study also identified three patients bearing blocking antibodies against IL-6, IL-22, and IL-12p70 (105)

10.1021/acs.molpharmaceut.6b00562 67 LuC.ZhangF.XuW.WuX.LianN.JinH.et al (2015)

CrossRef Fibroblast growth factor-21 prevents diabetic cardiomyopathy via AMPK-mediated antioxidation and lipid-lowering effects in the heart Hong Yang, Anyun Feng, Sundong Lin, Lechu Yu, Xiufei Lin, Xiaoqing Yan, Xuemian Lu, Chi Zhang Cell Death & Disease.2018;[Epub] CrossRef Salusin- contributes to oxidative stress and inflammation in diabetic cardiomyopathy Ming-Xia Zhao, Bing Zhou, Li Ling, Xiao-Qing Xiong, Feng Zhang, Qi Chen, Yue-Hua Li, Yu-Ming Kang, Guo-Qing Zhu Cell Death & Disease.2017