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However, the cause of the density decrease must be first elucidated, whether is caused by a direct cell death already shown in previous studies 37,38,39 , whether is due to an impairment on the remarkable neurogenic role of hippocampus, especially the latter, considering the period of fluoride exposure ended with the CNS fully developed 29 , with 81-days-old, which corroborates with the dual suggestive pathways of our findings regarding the developmental fluoride neurotoxicity 30,40

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