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Edited by Professor Boyi Gan Rights and permissions Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made

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Well-designed RCTs with large sample size and hard endpoints are needed to draw definite conclusions regarding the beneficial effects of NAC in uremic populations