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10.1016/s0045-6535(03)00213-3 Chemosphere 108 HoekstraE

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Mechanisms of neurodegeneration and axonal dysfunction in multiple sclerosis

While immortalized cell lines and conventional animal models are valuable, they do not accurately replicate the complex physiological and biochemical features of the human CNS in vivo

Whereas proper internal duct development is dependent on testosterone as the intracellular mediator, development of the urogenital sinus and tubercle into the external genitalia, urethra and prostate requires conversion of testosterone to dihydrotestosterone (DHT) by the isoenzyme 5-reductase-2