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In liver and intestinal epithelial cells, baicalein undergoes further metabolism by CYP450 enzymes, resulting in hydroxylation or demethylation reactions that produce metabolites such as 8-hydroxybaicalein and 4-hydroxybaicalein (Figure 2 M1) (Xie et al., 2020)

(4369:) peptidylglycine alpha-amidating monooxygenase COOH-terminalinteractor [Homo sapiens]

Lewy bodies form as reactive oxygen species derived from dysfunctional mitochondria damage structural components of the cell called microtubules

10.14642/RENC.2015.21.2.5099 99

Principal Component Analyses (PCA) was performed on the VST counts matrix for the 25 genes signature