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It is important to note that both human and hamster P-gp contain the same epitope sequence for C219 mAb [26], hence differences in antibody antigen binding is not responsible for differences in P-gp signal in the two cell lines

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Median nerve: This nerve provides feeling to most of the fingers in the hand (except the little finger)

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After phosphorylation, -arrestin 2 is recruited to the plasma membrane to bind with MOR and prevent the further activation of G protein to realize desensitization [87], accelerating the uncoupling of MOR with G protein, forming receptorprotein complexes (MOR/-arrestin 2/Adaptin-2/Clathrin) at the same time to promote the internalization of MOR until the internalization is suspended by dynamin [21,87,88,89]