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Hierarchical clustering of commonly engaged proteins by the fold increase in target engagement in senescent versus non-senescent conditions (referred to as senescence selectivity) identified broadly highly-reactive proteins, clusters of proteins with specificity to certain chemotypes and others (such as GPX4) that were enriched in probes related to three different SCLAs (Fig

Management of lung cancer in the patient with interstitial lung disease

They may reverse steroid resistance by countering oxidative inflammatory pathways and enhance the efficacy of phosphodiesterase-4 (PDE4) inhibitors (e.g., roflumilast), particularly in neutrophilic asthma (165)