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Elevated spermidine and total PA concentrations were also detected in fibroblasts obtained from SZ patients (95)

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The ARID1A gene, a tumor suppressor, encodes a key subunit of the SWI/SNF chromatin remodeling complex, which regulates gene expression by altering chromatin structure (112)

These effects possibly result from its potential to inhibit or alter cytochrome P450 enzymes (CYP3A4, CYP2D6), leading to increased drug levels and overlapping side effects including gastrointestinal distress and myalgia