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Youve probably noticed it goes away when your workout (or even that particular exercise) ends

Histone acetyltransferase p300 decreased in senescent hUC-MSCs at late passage, p300 inhibition induced premature senescence and decreased proliferation of hUC-MSCs [110]

The fact that it grew out of a big NIH grant may mean it has a better shot at getting a nice, fat NIH grant that is able to determine if a systemic energy drain is present in the immune system, if its affecting the rest of the body, and the best way to address the mitochondrial/oxidative stress issues found.

Hayes and McLellan Reference Hayes and McLellan1999)

It is also associated with inflammation and oxidative stress, along with other pathological processes (195)