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[DOI] [PMC free article] [PubMed] [Google Scholar] Zaplatic, E

References 8 and 10 show that DNMT3L interacts with unmethylated H3K4 through its N terminus and with DNMT3A through its C terminus, thus linking the DNA methylation machinery to the modification state of histone tails

In addition, the increased production of pro-inflammatory cytokines induced by gut dysbiosis, potentially compromises the BBB integrity [19], leading to the entry of toxins, peripheral inflammatory compounds, and T cells into the brain

In all cases treatment with pyridoxine or PLP itself alleviates the seizure tendency ( It has been hypothesized that a deficiency of PLP may cause seizures through suboptimal inhibitory GABAergic neurotransmission