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doi: 10.1038/s41590-024-01943-5 164 LinXYuTZhangLChenSChenXLiaoYet al

335 Astrocytes in post-mortem samples of patients with mesial temporal lobe epilepsy show significant down-regulation of K ir 4.1 channels critical for K + buffering

Therefore, clonidine therapy must always be tapered gradually over a minimum of 2 to 4 days (or weeks for higher doses), and any concurrent beta-blockers must be discontinued several days prior to beginning the taper (JAVADIN, 2025