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This action was found to be mediated by protein kinase A (PKA) and mitogen-activated protein kinase (MAPK) in neuronal PC12D cells [53, 194]

Additionally, these studies continue to demonstrate that GPX4 deletion can cause oxidative damage to membranes and exacerbate neuroinflammation

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Finally, the monoclonal antibody MRA003US is currently in a phase I trial (NCT00046774) and no results have been released to date