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4.2.2.2 Metabolic significance of phenylacetylglutamine Phenylacetylglutamine (PAGln) is a gut microbiota-dependent metabolite that has attracted considerable attention in recent years, formed from dietary phenylalanine metabolized by gut microbiota to phenylacetic acid and subsequently conjugated with glutamine in the liver (126)

doi:10.2174/1381612826666200523180301 National Center for Biotechnology Information

In two of the OPM-2 xenografts, BSO+L-PAM reduced tumor volumes of 1330 mm 3 and 972 mm 3 to 2), inducing CRs in majority of the mice treated (21/25), achieving MCRs in 6/25 mice, and doubling the median EFS relative to L-PAM alone ( P 80% was not cytotoxic, whereas three cell lines were affected by BSO

Li R, Raber M, Chandra J

J Natl Cancer Inst 89(17):1271-6, 1997