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Moreover, emerging evidence indicates that CNMs can be fermented by gut bacteria into bioactive metabolites like butyrate, which then modulate host physiology, such as intestinal stem cell differentiation highlighting not only toxicological but also transformative microbialhost interactions ( in vitro systems such as gut-on-chip platforms are increasingly integrated into tiered risk frameworks to enhance hazard identification without excessive animal use

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ACS Omega 9:2785327871 Sekar V, Al-Ansari MM, Narenkumar J et al (2022) Synthesis of gold nanoparticles (AuNPs) with improved anti-diabetic, antioxidant and anti-microbial activity from Physalis minima

XuXOcanseyDPeiBZhangYWangNWangZet alResveratrol alleviates DSS-induced IBD in mice by regulating the intestinal microbiota-macrophage-arginine metabolism axis

Overall, SOD and GR have some predictive power for spinal fusion and degeneration severity, according to this study