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Subsequent therapeutic studies demonstrate that the BCL-2i ABT-199 exhibits single-agent efficacy in all 3 BCL-2 overexpressing AI models whereas Enza and ABT-199 combination manifests synergistic potency in inhibiting the AR + BCL-2 + (i.e., double-positive) LNCaP-AI

Psychiatric disorders associated with immune checkpoint inhibitors: A pharmacovigilance analysis of the FDA Adverse Event Reporting System (FAERS) database

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KPV interrupts this process by stabilizing IkB-alpha and blocking the nuclear translocation of the p65/RelA NF-kB subunit through competitive interference with the importin-alpha3 transport mechanism

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