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doi: 10.1089/109662002763003366 19

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4.1 Reduced oxidative and biosynthetic metabolism through the Krebs cycle Figure 4 prominently illustrates a decrease of Krebs cycle intermediates (citric, cis-aconitic, isocitric, 2-ketoglutaric, and succinic acids) and associated organic acids (trans-citric, 2-hydroxyglutaric, and methylcitric acids) as giraffe milk transitions from mid to late lactation

Further, the upregulation of REST in AKI suppressed GCLM transcription and reduced GCL enzymatic activity, leading to the downregulation of GSH and GPX4