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Comment: Some comments voiced opposition to the 90-day limitation we discussed in the comment solicitation

"However, we do know that hormones like vasopressin, aldosterone and renin that are associated with dehydration are higher in people who have a hangover

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Similarly, we proposed to revise 414.84(b)(2) for 9 percent weight loss

The search strategy included irritable bowel syndrome, IBS, gut microbiota, dysbiosis, and microbiome, as well as combinations of keywords related to interventions such as probiotics, prebiotics, FMT, diet, and antibiotics, and combinations of keywords related to mechanisms such as gut-brain axis, visceral hypersensitivity, intestinal permeability, immune activation, stress, and gut microbial metabolites. Our inclusion criteria prioritized: (1) high-impact studies such as systematic reviews, meta-analyses, and large, well-designed randomized controlled trials (RCTs)