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The NF1 gene encodes neurofibromin, a GTPase-activating protein (GAP) that negatively regulates the oncoprotein RAS

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In addition, a clinical study reported that NIN administration may be useful for treating NAFLD by modulating energy balance, glucose and lipid metabolism, oxidative stress, and inflammation through different mechanisms (Naeini et al., 2021)

Therefore, elevated GGT expression increases tumor cell resistance to ferroptosis, safeguarding cells from ROS and lipid peroxidation, thus driving tumor cell proliferation, metastasis and chemotherapy drug resistance (85,107)