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In senescent cells, accumulated DNA damage can activate the tumor protein 53 (p53) signaling pathway, leading to the suppression of CTCF expression

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Cell-Autonomous Regulation of Astrocyte Activation by the Circadian Clock Protein BMAL1 papers.ssrn.com Abstract Circadian clock dysfunction is a common symptom of aging and neurodegenerative diseases, though its impact on brain health is poorly understood