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Ongoing phase 3 trials for weight loss in non-T2D individuals are now utilizing a similar dosing protocol to that of semaglutide, starting at 0.25 mg/week with gradual titration every four weeks, up to a maximum of 2.4 mg/week [11]

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This active compound is likely to inhibit the activation of nuclear factor-B (NF-B) through the TLR4/MAPKs/NF-B pathways, thus downregulating the expression of pro-inflammatory cytokines, including IL-1, IL-6, and TNF-

This migration leads to an inflammatory response and results in cardiac myocyte hypertrophy (116)

the cytotoxic agents exemplified with this strategy include anthracyclines, taxanes, mitomycin C, and the auristatins