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However, rather than directly affecting FAO, SCAP deficiency suppressed regulation of genes involved in sterol biosynthesis, including critical enzymes such as 3-hydroxy-3-methylglutaryl coenzyme A reductase

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55,56 Its pathogenesis is highly complex, involving the interplay of factors including lipid metabolism disorders, 57 insulin resistance, 10 oxidative stress, 58 immune activation, 13 and gut microbiota dysbiosis

One batch works, the next one does not