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10.11604/pamj.2019.33.286.17978 [DOI] [PMC free article] [PubMed] [Google Scholar] 166.Rusy LM, Weisman SJ, Hainsworth KR

Hypoxia causes trophoblast cell ferroptosis to induce miscarriage through lnc-HZ06/HIF1-SUMO/NCOA4 axis

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Results GSH depletion induces cell death in RPE cells To evaluate the effect of GSH depletion on the RPE cells, we used three different approaches: depletion of Cys 2 from cell culture media, treatment with buthionine sulphoximine (BSO, 1000 M) to block de novo synthesis of GSH, or treatment with erastin (10 M), an inhibitor of system x c 1