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Furthermore, the measure also stratifies (that is, sub-groups) episodes based on whether the patient had a metastatic cancer diagnosis or metastatic cancer drug usage in the year prior to the episode start

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Mechanistically, we found that insufficiency of vitamin B 12 during OSKM reprogramming resulted in changes in the bulk levels of many histone methylation marks, including a failure to properly trimethylate H3K36 at transcribed gene bodies, leading to increased levels of CT

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