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Recent investigations suggest that modulating some of these pathways, such as the MEK-ERK pathway and redox-sensitive pathways implicated in viral infections, can reduce ROS levels in vivo , correlating with diminished stone formation in animal models ( 2 ROS 2.1 Definition and production pathway of reactive oxygen species ROS, including free radicals, atoms, or molecules with unpaired electrons and their metabolites, comprise oxygen radicals like superoxide anion radicals (O 2 ) and hydroxyl radicals (OH), as well as non-radical oxidants such as hydrogen peroxide (H 2 O 2 ) and singlet oxygen (O 2 )

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doi:10.1038/s41467-022-32420-y