Theories include alteration of bile acid metabolism, small intestinal bacterial overgrowth, effects on intestinal motility and interference by metformin on vitamin B12-intrinsic factor absorption in the terminal ileum
Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene
These flexible troche molds allow compounders to make as many or as few troches as they need, and then remove the troches and place them in blister packs, which may be easier for patients to use and may help with patient compliance
Regarding cardiac risk, the lorcaserin group was non-inferior to the placebo group with slightly better values in cardiac risk factors (blood pressure, heart rate, glycemic control, lipid profile)
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