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For in vivo use of antibodies in humans, it may be preferable to use humanized chimeric monoclonal antibodies

On one hand, oxidative stress can reduce the production of NO and interfere with the NO signaling pathway by oxidatively modifying NO target proteins (32)

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RCT: NAC Augmentation of Clozapine Neill et al 11 described an investigator-initiated, industry-independent, moderately large (n = 84), well-designed, well-conducted, well-analyzed, 52-week RCT of NAC (2 g/d) in schizophrenia patients with persistent symptoms that were refractory to at least 3 classes of antipsychotic drugs as well as to 6 months of treatment with their current medication, clozapine

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