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SakakibaraY.YanagisawaK.KatafuchiJ.RingerD

doi: 10.2147/IJN.S321984 Summary Keywords cancer immunotherapy, covalent organic frameworks, immunogenic cell death, immunosuppressive tumor microenvironment, photodynamic therapy Citation Zou Y, Chen M, Chen J, Wang W and Zheng X (2026) Covalent organic frameworks for cancer immunotherapy: mechanisms, applications, and prospects

[54] In HepG2 cell lines, eugenol protects human liver HepG2 cells from H 2 O 2 -induced oxidative hepatotoxicity by maintaining ROS homeostasis, increasing IL-10 levels, and upregulating cytochrome gene expression

RTAs often lack target engagement biomarkers or companion diagnostics, making it difficult to confirm whether they reach and modulate the intended ferroptotic pathways in vivo