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The metabolic profile is very similar to that in column 3 except that now the intracellular SAH concentration does not decline but instead increases by 24% in line with the clinical data

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2.2 Metformin alleviates endoplasmic reticulum (ER) stress ER stress refers to a homeostatic imbalance within the ER caused by external stimulus or changes in the intracellular environment, which further leads to the accumulation of unfolded or misfolded proteins in the ER

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Anyone considering treatment should discuss it with a healthcare professional before receiving a B12 deficiency injection