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Haigis MC, Guarente LP (2006) Mammalian sirtuinsemerging roles in physiology, aging, and calorie restriction

In people with true deficiency, B12 injections bring obvious benefits quickly

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However, annual review with your GP is advisable to: Ensure adherence to the injection schedule Monitor for any new or worsening symptoms Consider testing for other autoimmune conditions if symptoms develop (particularly thyroid function, as thyroid disease is commonly associated with pernicious anaemia) [2] Gastric cancer risk: Pernicious anaemia is associated with a slightly increased risk of gastric cancer