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TeraoMGoracciLCelestiniVKurosakiMBolisMdi VeroliAet al

Oxidative stress can damage sperm DNA, proteins, and membranes, compromising sperm function

These observations qualified the HepG2 model to study the mechanisms described herein

Comprehensive proteome profiling identified 3713 proteins, including 591 unique to HMC3, distinguishing this line molecularly from C20 microglia and revealing enrichment of pathways associated with mitochondrial oxidative phosphorylation, ribosomal translation, DNA repair, cell-cycle regulation, and antiviral immunity

however, its function in other tissues, especially during erythropoiesis, is poorly understood