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1.1 Tobaccos enduring impact Tobaccos journey through the centuries is intertwined with human history, from its supposed medicinal use by indigenous people to its rapid global spread following Columbus arrival in America [3]

Future research through large-scale, multiethnic longitudinal studies and clinical trials is crucial to establish a cause-and-effect relationship, provide conclusive insights into genetic factors, and fully understand the impact of smoking on prostate cancer biology, potentially revealing therapeutic targets and fully understand the effects of smoking on prostate cancer biology, potentially revealing therapeutic targets

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Definition of changes in smoking habit Data regarding smoking habits were collected using a self-reported structured questionnaire at the time of the health checkup within 2 years before and after the index IS

First of all, try not to be too hard on yourself