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Figure 12A, B shows a significant decline in the anti-apoptotic protein Bcl-2 and a notable increase in the proapoptotic protein Bax

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With advancements in dermatology, treatments like laser therapy, glutathione injections, and chemical peels have become highly effective solutions

Collectively, the synergistic action of AGE-RAGE signaling, metabolic rewiring, and oxidative stress in the DW microenvironment creates a powerful, self-reinforcing circuit that locks macrophages into a persistent M1 state, thereby perpetuating chronic inflammation and impeding the resolution of healing (Figure 3)

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