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Autoantibody production leads to the immune systems attack on intrinsic factor

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Excess biotinylating agent was quenched and removed with three washes of PBS supplemented with 0.1 M glycine and cells were homogenized using a lysis buffer (150 mM NaCl, 20 mM Tris, and 1% Triton X-100, pH 7.5) containing protease inhibitors (Roche)

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A culture that prioritizes schedule or cost over compliance fosters the very lapses, poor aseptic technique, inadequate documentation, ineffective CAPAs, that dominate enforcement actions

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