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These mechanisms support both functional repair and optimization of tissue architecture at a systemic level

doi: 10.1016/j.fertnstert.2003.10.034 33 MicicSLalicNDjordjevicDBojanicNBogavac-StanojevicNBusettoGM

Int J Androl 19(5):307313 Dong JY, Zhang YH, Qin LQ (2011) Erectile dysfunction and risk of cardiovascular disease: meta-analysis of prospective cohort studies

The common allele is cytoprotective against the toxic effects of chemotherapeutics, whereas the functionally less competent allele is thought to increase the toxicity of anticancerogenic drugs in patients with this gene variant due to decreased metabolic activity of impaired enzyme