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One of these antibodies reacts with thyroid cells and orbital fibroblasts, triggering inflammation in the orbital muscles, connective tissues, adipose deposits, and tear-producing glands

Blockade of interferon-gamma normalizes interferon-regulated gene expression and serum CXCL10 levels in patients with systemic lupus erythematosus

& Germain, D

Indeed, it is known that Nrf2 is a master factor for the regulation of antioxidant response elements (ARE) in several antioxidant and phase II detoxifying proteins in different cell types, including nerve cells (Kobayashi and Yamamoto, 2013), and several reports have shown that although DHA itself does not bind Nrf2, it may stimulate transcriptional activity of ARE-containing genes through activation of Nrf2 upon generation of 4-hydroxy-2-hexenal, which indeed activates Nrf2 (Ishikado et al., 2013)

These findings seem to indicate that surgical intervention will remain a necessary component of care for patients with lateral epicondylitis who are not cured by Botulinum toxin injection or other, more common treatment modalitiesand that we should pay attention to improving surgical outcomes