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Dual-responsive, methotrexate-loaded, ascorbic acid-derived micelles exert anti-tumor and anti-metastatic effects by inhibiting NF-B signaling in an orthotopic mouse model of human choriocarcinoma

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While the effects of these agents on DNA damage were only observed with pretreatment, all the antioxidants did show significant protective effects against radiation-induced lipid peroxidation, even when administered after irradiation [38]